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Ask me anything

· July 29, 2020

AMA: Orrin Ailloni-Charas — From MD to MBA to Fund Manager

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My name is Orrin Ailloni-Charas, MD, MBA, and I am the CEO and Managing Partner of the Global Health Impact Fund. I am fortunate to have had extensive experience in both clinical medicine and venture capital.  After graduating from the University of Pennsylvania and the NYU School of Medicine, I trained in anesthesia at the Mount Sinai Hospital in New York City and then practiced anesthesia for nearly 25 years, first in New York City and then in the Bay Area. Before moving to California, I completed my MBA at Columbia University and had my first experience in venture capital with Silicon Alley Venture Partners.  

At my anesthesia practice at CPMC in San Francisco, I held positions as Executive Board Member and CFO for 13 years.  During this time, I also held consulting positions at HealthTap and Pacira.  In 2016, I joined a startup called AngelMD, which brought physicians together to support and invest in healthcare innovation.  As an early employee, I was responsible for developing startup analytics to help inform investors,  building an extensive expert network, and optimizing a process to allow for SEC-compliant, syndicate investing. During my tenure, I led the efforts that raised over $12 million of capital for several startups.  

After leaving AngelMD in 2018, I joined RedCrow as Managing Director where I developed a quantitative and qualitative, comprehensive analysis for healthcare startups to provide even greater insight for investors than I had done previously.  During this time, I partnered with NASDAQ, through their Entrepreneurial Center in San Francisco, to produce, develop, and host a web-based show, RedCrow Healthcare Innovators Unplugged. My team also had the privilege of sponsoring the Cleveland Clinic Medical Innovation Summit in 2017 and 2018. At the summit in 2018, I hosted and judged the Cleveland Clinic Innovations Pitch Event. 

Chasing an out-sized ROI surely is an important component of my role at the GHIF, as well as being a responsible steward of our LPs’ investments. However, my passion has always been to leverage my expertise and insight, earned over many years in clinical practice,  with my experiences in business and finance to source, invest, and support healthcare startups that can help improve health and well-being at scale. 

Republic Venture Partner AMA (Ask Me Anything) is a weekly series. Feel free to ask questions in the discussion section below.* He will be answering questions Wednesday 7/29 through Friday 7/31 so submit your questions now!

*must sign into Republic account to ask questions — register here first!


This educational article is provided by Republic to help its users understand this area of the market, it should not be construed as investment advice as it is impersonal, disinterested and was produced by Republic for Republic’s users, without remuneration received or expected.

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Profile picture of Bob Sweeney
Bob Sweeney
almost 6 years ago
Orrin: Can you explain the function of management fees as a cost for investors? Are these fees typically reimbursed from future distributions?
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Profile picture of Orrin Ailloni-Charas
Orrin Ailloni-Charas Thanks, @bob-sweeney It is common practice for a venture fund to charge management fees in order to pay salaries, legal fees, accounting fees, etc. expenses to run the fun typically are covered by these fees. These fees are not commonly reimbursed, but each fund can individualize its approach. Our fund, GHIF Fund 1, for example, refunds the management fee prior to taking any GP distribution.
Almost 6 years ago
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Almost 6 years ago
Profile picture of Andrew Zhang
Andrew Zhang
almost 6 years ago
Question submitted via @joinrepublic by @thenameis_pajju:
"What do you say about the role of networks with investing?"
ADD. Do you know about the Pi Network and what are your thoughts on the network?
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Profile picture of Orrin Ailloni-Charas
Orrin Ailloni-Charas Thanks, @thenameis_pajju @andrew-zhang-1
I think networks, when leveraged properly, can be extremely valuable throughout the life cycle of the investment. For my fund, the Global Health Impact Fund, we have a strategic network of physicians and other healthcare stakeholders that support our work in the following ways: deal sourcing, due diligence, advisory support, and relationship management. Each of these components add value and, collectively, positively differentiate and investment from my fund from other investors.
Almost 6 years ago
1 like
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Almost 6 years ago
Profile picture of Orrin Ailloni-Charas
Orrin Ailloni-Charas Btw, I’m not familiar with the Pi Network. If its the crypto network, its out of my wheelhouse.
Almost 6 years ago
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Almost 6 years ago
Profile picture of Chris Kager
Chris Kager
almost 6 years ago
So a softball to start: what are the most important things that you look at on first pass when evaluating an early stage startup for funding?
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Profile picture of Orrin Ailloni-Charas
Orrin Ailloni-Charas Hi @chris-kager,
Thanks for the question. My first pass usually focuses on clinical issues, such as impact, clinical integration, underlying science, and need. If those components don’t pan out, I usually don’t perform a deeper diligence.
Almost 6 years ago
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Almost 6 years ago
Profile picture of Orrin Ailloni-Charas
Orrin Ailloni-Charas
almost 6 years ago
Hi everyone, I’m excited to do my first AMA. Please be gentle:)
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